Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (6): 2245-2251.DOI: 10.6023/cjoc202211014 Previous Articles     Next Articles


邢凤a,b, 曾浩a, 李茜a, 万丹a, 丁欢欢a, 谢江c, 陈琳a,*(), 周先礼a,b,c,*()   

  1. a 西南交通大学生命科学与工程学院 成都 610031
    b 西南交通大学教育部材料先进技术重点实验室 成都 610031
    c 西南交通大学附属医院成都第三人民医院 成都 610031
  • 收稿日期:2022-11-10 修回日期:2022-12-21 发布日期:2023-01-11
  • 基金资助:
    国家自然科学基金(82073734); 四川省应用基础(2021YJ0222); 四川省中医药管理研究基金(2020HJZX002); 中央高校基本科研业务费专项(2682021CX085); 大学生创新创业培训计划(202210613076)

Three New C19-Diterpenoid Alkaloids from Aconitum brevicalcaratum

Feng Xinga,b, Hao Zenga, Qian Lia, Dan Wana, Huanhuan Dinga, Jiang Xiec, Lin Chena,*(), Xianli Zhoua,b,c,*()   

  1. a School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031
    b Key laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031
    c Affiliated Hospital of Southwest Jiaotong University & The Third People Hospital of Chengdu, Chengdu 610031
  • Received:2022-11-10 Revised:2022-12-21 Published:2023-01-11
  • Contact: E-mail:;
  • Supported by:
    National Natural Foundation of China(82073734); Science and Technology Support Programs of Sichuan Province(2021YJ0222); Research Foundation for Administration of Traditional Chinese Medicine of Sichuan Province(2020HJZX002); Fundamental Research Funds for Central Universities(2682021CX085); College Students' Innovative Entrepreneurial Training Plan Program(202210613076)

Three new C19-diterpenoid alkaloids, brevicalcarines A~C (1~3), together with seven known compounds (4~10), were isolated from the roots of A. brevicalcaratum (Finet et Gagnep.) Diels. Their structures were determined by HR-ESI-MS (high resolution electrospray ionization mass spectroscopy), IR (Infrared absorption spectroscopy), 1D NMR (One-dimensional nuclear magnetic resonance), 2D NMR (Two-dimensional nuclear magnetic resonance) and X-ray crystallographic analysis. Brevicalcarine A (1) was a new diterpenoid alkaloid with vaginatunine A fragment at C-18, while brevicalcarine B (2) and brevicalcarine C (3) were new C19-diterpenoid alkaloid with an acetoxy group at C-18. In addition, the anti-neuroinflammatory activity of these compounds against BV-2 cells was investigated, which showed that none of them had significant anti-neuroinflammatory activity.

Key words: ranunculaceae, Aconitum brevicalcaratum, diterpenoid alkaloid, anti-neuroinflammatory activity