Synthesis of four stereoisomeric 3\b\,17-dihydroxy-16-amino-5\a-androstanes

Abstract

Starting from epiandrosterone, intermediates 3b-hydroxy-5a-androst-16-ene (I) and 3b-hydroxy-16a-bromo-5a-androst-17-one (II) were synthesized. 3b,17a-Dihydroxy-16a-amino-5a-androstane and its 16b-amino isomer were obtained from I; 3b, 17b-dihydroxy-16a-amino-5a-androstane and its 16b-amino isomer from II. The configurations of these four stereoisomers were confirmed via chem. conversions and spectral data.

Key words: SODIUM COMPOUNDS, AZIDE, STEREOISOMERISM, ANDROSTANES, CONFIGURATION, ALUMINIUM LITHIUM HYD

CLC Number:

O629

Cite this article

ZHAO MING;LIAO QINGJIANG;XIANG MANWEN. Synthesis of four stereoisomeric 3\b\,17-dihydroxy-16-amino-5\a-androstanes[J]. Chin. J. Org. Chem., 1987, 7(1): 34-40.

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