Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (4): 1365-1385.DOI: 10.6023/cjoc202209022 Previous Articles     Next Articles


有机叠氮化合物参与的反应: C—N3基团保留的研究进展

魏芳*(), 余鑫, 肖强*()   

  1. 江西科技师范大学有机功能分子研究所 南昌 330013
  • 收稿日期:2022-09-17 修回日期:2022-10-22 发布日期:2022-11-21
  • 通讯作者: 魏芳, 肖强
  • 基金资助:
    江西省教育厅基金(GJJ190617); 江西科技师范大学博士启动基金(2019BSQD007)

Advances in C—N3 Retention Reactions Involving Organic Azides

Fang Wei(), Xin Yu, Qiang Xiao()   

  1. Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013
  • Received:2022-09-17 Revised:2022-10-22 Published:2022-11-21
  • Contact: Fang Wei, Qiang Xiao
  • Supported by:
    Education Department of Jiangxi Province(GJJ190617); PhD Start-Up Funds of Jiangxi Science & Technology Normal University(2019BSQD007)

Organic azides are widely used in the total synthesis of natural products, medicinal chemistry and material chemistry. Azides tend to release molecular nitrogen to construct nitrogen-containing heterocycles or amino compounds. However, the retention of azide is necessary in the critical synthesis steps of some natural products. The types of C—N3 retention in organic reactions are summarized, including cycloaddition, addition with unsaturated bond, Winstein rearrangement and 1,2-migration.

Key words: organic azide, C—N3 bond, cycloaddition, rearrangement