Chin. J. Org. Chem. ›› 1993, Vol. 13 ›› Issue (3): 314-321. Previous Articles     Next Articles

Original Articles

手征性5,5-二甲基-4,6一次甲基-2-甲基羰基-2-环己烯酮的选择性Diels-Alder反应在全合成青蒿素中的应用

刘行让   

  1. 加拿大阿尔贝托大学化学系
  • 发布日期:1993-06-25

Facile selective diels-alder reactions of chiral 5,5-dimethyl-4,6- methano-2-methoxycarbonyl-2-cyclohexenone,application to the total synthesis of qinghaosu

LIU XINGRANG   

  • Published:1993-06-25

A review with 19 refs., starting from (-)-b-pinene (I), an efficient synthesis of qinghaosu (II) in natural form has been accomplished. The synthesis involves keto ester (III) as a key intermediate which is conveniently prepared using the Diels-Alder chem. developed in the authors' laboratory, i.e., reaction of ketone IV and isoprene in presence of Lewis acid.

Key words: ARTEANNUIN, DIELS-ALDER REACTION, BUTADIENE

CLC Number: