Synthesis of Different 3,4-Dihydropyrimidin-2(1H)-one Cata-lyzed by Inorganic Zinc Compounds

Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (03): 333-336. Previous Articles Next Articles

Original Articles

无机锌盐催化脂肪醛的Biginelli反应

王彩凤¹，姜恒*^,1，宫红¹，王敏²，王之昌²

(¹辽宁石油化工大学石化学院抚顺 113001)
(²东北大学理学院化学系沈阳 110004)

收稿日期:2005-08-22 修回日期:2005-09-22 发布日期:2006-02-28
通讯作者: 姜恒

Synthesis of Different 3,4-Dihydropyrimidin-2(1H)-one Cata-lyzed by Inorganic Zinc Compounds

WANG Cai-Feng¹,JIANG Heng*^,1,GONG Hong¹,WANG Min²,WANG Zhi-Chang²

(¹ Liaoning University of Petroleum and Chemical Technology, Fushun 113001)
(² Department of Chemistry, School of Sciences, Northeastern Univer-sity, Shenyang 110004)

Received:2005-08-22 Revised:2005-09-22 Published:2006-02-28
Contact: JIANG Heng

Abstract

Inorganic zinc compounds of nitrate, sulfate, chloride and acetate catalyzed one pot Biginelli reaction was investigated by using ethanol as solvent under refluxing temperature. Seven aliphatic aldehydes, 1,3-dicarbonyl compounds and urea were used as raw material. The results show that the activity of zinc nitrate was better than those of the other three with the highest yield of 94%. The target products were identified by FTIR and ¹H NMR analysis. The advantages of this one pot Biginelli con-densation were simple operation, inexpensive cost and easily obtained catalyst.

Key words: zinc nitrate, 3,4-dihydropyrimidin-2(1H)-one, aliphatic aldehyde

Cite this article

WANG Cai-Feng,JIANG Heng*^,1,GONG Hong,WANG Min²,WANG Zhi-Chang². Synthesis of Different 3,4-Dihydropyrimidin-2(1H)-one Cata-lyzed by Inorganic Zinc Compounds[J]. Chin. J. Org. Chem., 2006, 26(03): 333-336.

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无机锌盐催化脂肪醛的Biginelli反应

Synthesis of Different 3,4-Dihydropyrimidin-2(1H)-one Cata-lyzed by Inorganic Zinc Compounds

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