Four intermediates of glycidyl ethers, namely ethyl glycidyl ether (1), propyl glycidyl ether (2), butyl glycidyl ether (3) and amyl glycidyl ether (4), were obtained through a phase-transfer catalytic methodology using acyclic alcohol and epichlorohydrin as raw materials. To choose 1.5% or 30% of sodium hydroxide solution as the environmental media, subsequent procedures were conducted with these glycidyl ethers and β-cyclodextrin. The products were isolated through a self packed silica gel column chromatography, and their chemical structures were proved to be the mono substituted 2-(3-alkyloxy-2-hydroxypropyl)- β-cyclodextrins (1a～4a) and mono substituted 6-(3-alkyloxy-2-hydroxypropyl)-β-cyclodextrins (2b～4b) by means of the TLC, IR, DSC, MS, ¹H NMR and ¹³C NMR measurements.

Key words: glycidyl ether, epichlorohydrin, 3-alkyloxy-2-hydroxypropyl-β- cyclodextrin, β-cyclodextrin derivative