Synthesis, Structure and Antitumour Activity of Phenyl-(trimethylsilylmethyl)tin Arylcarboxylates

Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (06): 856-859. Previous Articles Next Articles

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苯基(三甲基硅基亚甲基)锡二芳香酸酯的合成、结构和抗癌活性

林森*^,1,2，付志飞¹，何小立¹,2，刘环宇¹，孙小强²,3
汪信²，陆路德²

(¹南昌大学化学系南昌 330047)
(²南京理工大学化工学院南京 210094)
(³江苏工业学院常州 213016)

收稿日期:2005-09-21 修回日期:2005-12-22 发布日期:2006-05-31
通讯作者: 林森

Synthesis, Structure and Antitumour Activity of Phenyl-(trimethylsilylmethyl)tin Arylcarboxylates

LIN Sen*^,1,2,FU Zhi-Fei¹,HE Xiao-Li¹,2,LIU Huan-Yu¹,SUN Xiao-Qiang²,3
WANG Xin²,LU Lu-De²

(¹ Department of Chemistry, Nanchang University, Nanchang 330047)
(² School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094)
(³ Jiangsu Polytechnic University, Changzhou 213016)

Received:2005-09-21 Revised:2005-12-22 Published:2006-05-31
Contact: LIN Sen

Abstract

Ten phenyl-(trimethylsilylmethyl)tin arylcarboxylates have been synthesized by the reaction of phenyl-(trimethylsilylmethyl)tin dibromide with arylcarboxylic acids. Their structures were characterized by elemental analysis, IR, ¹H NMR and ¹³C NMR spectra. The preliminary bioassay tests showed that they had a good antitumour activity in vitro against Hela and SPC-A-1 tumour cells.

Key words: structure, antitumour activity, synthesis, mixed diorganotin compound

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LIN Sen*^,1,2,FU Zhi-Fei,HE Xiao-Li^1,2,LIU Huan-Yu,SUN Xiao-Qiang^2,3
WANG Xin²,LU Lu-De^{2. Synthesis, Structure and Antitumour Activity of Phenyl-(trimethylsilylmethyl)tin Arylcarboxylates[J]. Chin. J. Org. Chem., 2006, 26(06): 856-859.}

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苯基(三甲基硅基亚甲基)锡二芳香酸酯的合成、结构和抗癌活性

Synthesis, Structure and Antitumour Activity of Phenyl-(trimethylsilylmethyl)tin Arylcarboxylates

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