Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (10): 1394-1397. Previous Articles     Next Articles

Original Articles



  1. (a军事医学科学院放射与辐射医学研究所 北京 100850)
    (b江西中医学院 南昌 330006)
  • 收稿日期:2005-09-21 修回日期:2006-02-21 发布日期:2006-09-19
  • 通讯作者: 李庶心

An Efficient Synthesis of 9-β-D-2'-Deoxyribofuranosyl-6-methylpurine

LI Shu-Xin*,a,JIANG Fa-Longa,b,ZHAO Yan-Jina
GUO Jin-Huaa,WANG Zhi-Qinga   

  1. (a Institute of Radiation and Irradiation Medicine, Academy of Military Medical Science, Bei-jing 100850)
    (b Jiangxi Traditional Chinese Medicine of Institute, Nanchang 330006)
  • Received:2005-09-21 Revised:2006-02-21 Published:2006-09-19
  • Contact: LI Shu-Xin

A new method for preparing 9-β-D-2'-deoxyribofuranosyl-6-methylpurine from inosne (1) is described. Inosne was converted to 6-chlorolpurinenucleoside (4) via esteriflcation, chlorination and deacetylation, then through protecting, deacetylation and deprotecting reactions to give the key intermediate 6-methylpurinenucleoside (7). The compound 7 was protected with O[Si(i-Pr)2Cl]2 and reacted with phenyl carbonochloridothioate to give compound 9. The compound 9 was converted to target compound 11 by reduction and deprotecting reaction. The structures of these products were identified by MS, 1H NMR spectra and elemental analysis.

Key words: purinenucleoside, synthesis, nucleoside