Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (07): 1018-1038. Previous Articles     Next Articles



李 宁a,b; 郗国宏a ; 吴秋华a ; 刘伟华a; 马晶军*,a; 王 春a   

  1. (a河北农业大学理学院 河北省生物无机化学重点实验室 保定 071001)
    (b河北农业大学食品科技学院 保定 071001)
  • 收稿日期:2008-08-18 修回日期:2008-11-03 发布日期:2009-07-22
  • 通讯作者: 马晶军

Organocatalytic Asymmetric Michael Additions

Li, Ning a,b; Xi, Guohong a; Wu, Qiuhua a; Liu, Weihua a ;
Ma, Jingjun*,a ; Wang, Chuna

  1. (a Hebei Key Laboratory of Bioinorganic Chemistry, College of Sciences, Agricultural University of Hebei, Baoding 071001)
    (b College of Food Science and Technology, Agricultural University of Hebei, Baoding 071001)
  • Received:2008-08-18 Revised:2008-11-03 Published:2009-07-22
  • Contact: Ma, Jingjun

Organocatalytic asymmetric reaction is an increasingly active area in organic synthesis. The asymmetric Michael addition provides a rapid access to versatile important chiral building blocks and intermediates for the synthesis of bioactive agrochemicals and pharmaceutical compounds. The reported organocatalyst for asymmetric Michael additions include proline and its derivatives, chiral imidazolidinone derivatives, chiral (thio) urea, cinchona alkaloids and so on. The applications of various organocatalysts to asymmetric Michael additions are reviewed in this paper. The reaction mechanism, catalytic activity and the asymmetric induction influenced by the structure of organocatalysts and the reaction condition are also discussed.

Key words: enantioselectivity, asymmetric Michael addition, organocatalysis