Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (11): 3640-3657.DOI: 10.6023/cjoc202205001 Previous Articles     Next Articles



闫辉, 张曼, 李琳, 胡腾, 杨武林*()   

  1. 华东理工大学药学院 上海市化学生物学重点实验室 上海 200237
  • 收稿日期:2022-05-01 修回日期:2022-06-13 发布日期:2022-06-29
  • 通讯作者: 杨武林
  • 基金资助:

Advances in the Catalytic Asymmetric Synthesis of Chiral Spiroketals

Hui Yan, Man Zhang, Lin Li, Teng Hu, Wulin Yang()   

  1. Shanghai Key Laboratory of Chemical Biology & School of Pharmacy, East China University of Science and Technology, Shanghai 200237
  • Received:2022-05-01 Revised:2022-06-13 Published:2022-06-29
  • Contact: Wulin Yang
  • Supported by:
    National Natural Science Foundation of China(22171081)

As an unique spiro skeleton, spiroketals are ubiquitous motifs in many natural products, biologically active molecules, and privileged chiral ligands. The development of efficient synthetic methods for the preparation of spiroketals has long been a hot research topic in organic synthesis. In particular, the remarkable advances regarding the catalytic asymmetric synthesis of chiral spiroketals have been achieved over the past decade. The progress in the field of catalytic asymmetric synthesis of chiral spiroketals is summarized according to the reaction types. The future development direction of this field is also prospected.

Key words: asymmetric catalysis, enantioselectivity, spiroketals