Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (07): 1048-1058. Previous Articles     Next Articles

Review

有机小分子催化的不对称Strecker反应研究进展

唐然肖 ; 李云鹏; 李越敏 ; 刘伟华;
马晶军; 王彦恩; 王 春*
  

  1. (河北农业大学理学院 保定 071001)

  • 收稿日期:2008-09-25 修回日期:2008-11-15 出版日期:2009-07-22 发布日期:2009-07-22
  • 通讯作者: 王 春

Developments in Organocatalytic Asymmetric Strecker Reactions

Tang, Ranxiao ; Li, Yunpeng; Li, Yuemin ; Liu, Weihua;
Ma, Jingjun; Wang, Yanen; Wang, Chun*
  

  1. (College of Science, Agricultural University of Hebei, Baoding 071001)
  • Received:2008-09-25 Revised:2008-11-15 Online:2009-07-22 Published:2009-07-22
  • Contact: Wang, Chun

Organocatalytic asymmetric reaction is an increasingly active area in oraganic sythesis. Asymmetric Strecker reaction is a powerful tool for the synthesis of α-amino acids. The reported organocatalysts for asymmetric Strecker reaction include chiral guanidines, chiral (thio)urea derivatives, N-oxide compounds, chiral Brønsted acids and so on, which can catalyze the asymmetric Strecker reaction with high catalytic activity and excellent enantioselectivity. The applications of various organocatalysts to asymmetric Strecker reactions are reviewed in this paper. The catalytic activity and the asymmetric induction influenced by the structure of organocatalysts and the reaction condition are also discussed.

Key words: enantioselectivity, asymmmetric Strecker reactio, organocatalysis