Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (12): 1811-1819. Previous Articles     Next Articles

Reviews

有机催化不对称Henry加成反应

高书涛1,郗国宏1李宁1,2王春1,马晶军*,1   

  1. (1河北农业大学理学院 河北省生物无机化学重点实验室 保定 071001)
    (2河北农业大学食品科技学院 保定 071001 )
  • 收稿日期:2009-06-22 修回日期:2010-02-07 出版日期:2010-12-20 发布日期:2010-06-10
  • 通讯作者: 马晶军 E-mail:majingjun@hebau.edu.cn
  • 基金资助:

    河北省自然科学基金(No 299158)和河北农业大学非生命学科和新兴学科科研发展基金资助项目

Organocatalytic Asymmetric Henry Reactions

Gao Shutao1 Xi Guohong1 Li Ning1,2 Wang Chun1 Ma Jing-jun*,1   

  1. (1 Hebei Key Laboratory of Bioinorganic Chemistry, College of Sciences, Agricultural Uni-versity of Hebei, Baoding 071001)
    (2 College of Food Science and Technology, Agricultural University of Hebei, Baoding 071001)
  • Received:2009-06-22 Revised:2010-02-07 Online:2010-12-20 Published:2010-06-10
  • Contact: Jing-Jun Ma E-mail:majingjun@hebau.edu.cn

Organocatalytic asymmetric reaction is an increasingly active area in organic synthesis. Asymmetric Henry reaction is a versatile tool for the synthesis of chiral nitro compounds. The reported organocatalysts for asymmetric Henry reaction include chiral guanidines, chiral (thio)urea derivatives, cinchona alkaloids and so on, which could catalyze the asymmetric Henry reaction with high catalytic activity and excellent enantioselectivity. The applications of various organocatalysts in asymmetric Henry reaction are reviewed in this paper. The reaction mechanism, catalytic activity and the asymmetric induction influenced by the structure of organocatalysts and the reaction conditions are also discussed.

Key words: organocatalysis, enantioselectivity, asymmetric Henry reaction