Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (06): 654-659. Previous Articles     Next Articles

Original Articles

合欢皮中两个新八糖苷的分离鉴定和活性研究

邹坤1,2,崔景荣3,冉福香3,王邠1
赵玉英*,1,张如意1,郑俊华1   

  1. (1北京大学药学院天然药物学系 北京 100083)
    (2三峡大学化学与生命科学学院 宜昌 443000)
    (3北京大学药学院天然药物及仿生药物国家重点实验室 北京 100083)
  • 收稿日期:2004-04-12 修回日期:2004-12-06 出版日期:2005-05-30 发布日期:2005-05-30
  • 通讯作者: 赵玉英

Structures and Activity of Two Novel Saponins from Albiza julibrissin

ZOU Kun1, CUI Jing-Rong3 , RAN Fu-Xiang3, WANG Bin1
ZHAO Yu-Ying*1, ZHANG Ru-Yi1, ZHENG Jun-Hua1   

  1. (1 School of Pharmaceutical Sciences, Peking University, Beijing 100083)
    (2 College of Chemistry and Life Sciences, China Three Gorges University, Yichang 443000)
    (3 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences,
    Peking University, Beijing 100083)
  • Received:2004-04-12 Revised:2004-12-06 Online:2005-05-30 Published:2005-05-30

Two triterpene saponins acylated with monoterpenoid were isolated from the stem barks of Albizia julibrissin. Their structures were identified as 3-O--D-xylopyranosyl-(1→2)--L-arabinopyranosyl- (1→6)-6--D-glucopyrano-syl-21-O-[(6S)-2-trans-2-hydroxymethyl-6-methyl-6-O-D-quinovopyranosyl- 2,7-octadienoyl]-acacic acid-28-O--D-glucopyranosyl-(1→3)-[α-2-arabinofuranosyl-(1→4)-α-L-rhomno- pyranosyl-(1→2)--D-glucopyranosylester (1) and 3-O--D-xylopyranosyl-(1→2)--L- arabinopyranosyl- (1→6)--D-2-deoxy-2-acetamidoglucopyranosyl-21-O-[(6S)-2-trans-2-hydroxymethyl-6-methyl-6-O--D- quinovopyranosyl-2,7-octadienoyl]-acacic acid-28-O--D-glucopyranosyl-(1→3)--L-arabinofuranosyl- (1→4)--L-rhamnopyranosyl-(1→2)--D-glucopyranosyl ester (2) based on chemical and spectroscopic methods, respectively, named as Julibrosides J25 and J22. Julibrosides J25 and J22 showed marked activities against four kinds of cancer cell lines in a concentration of 100 g/mL assayed by SRB method.

Key words: Albizia julibrissin, acetamidoglucoside, julibroside J25, julibroside J22, triterpenoid saponin