Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (5): 976-986.DOI: 10.6023/cjoc201511021 Previous Articles     Next Articles



苗志伟a,b, 蔡岩c, 葛海红b, 付嘉欣b, 木尼热·阿布都克力木a   

  1. a. 喀什大学化学与环境科学学院 喀什 844006;
    b. 南开大学元素有机化学研究所 天津 300071;
    c. 天津国际生物医药联合研究院 天津 300457
  • 收稿日期:2015-11-12 修回日期:2015-12-16 发布日期:2016-01-07
  • 通讯作者: 苗志伟, 木尼热·阿布都克力木
  • 基金资助:


Research Progress of α-Diazophosphonates

Miao Zhiweia,b, Cai Yanc, Ge Haihongb, Fu Jiaxinb, Abudukeremu Muniraa   

  1. a. College of Chemistry and Environmental Sciences, Kashgar University, Kashgar 844006;
    b. Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071 ;
    c. Tianjin International Joint Academy of Biomedicine, Tianjin 300457
  • Received:2015-11-12 Revised:2015-12-16 Published:2016-01-07
  • Supported by:

    Project supported by the Committee of Science and Technology of Tianjin City (No. 15JCYBJC20700) and the Xinjiang Laboratory of Native Medicinal and Edible Plant Resources Chemistry Open Subject (No. 2015KL030).

Diazo compounds are the most commonly used carbene precursors. They can be dediazonized to obtain highly reactive free carbene intermediates or metal cabenoid under transition metal catalysts. Then varieties of chemical transformations can be proceeded, such as X—H (X=C, N, O, S, Si, etc.) insertions, 1,2-hydrogen migration reactions and cyclopropanations. Varieties of pharmaceuticals, natural products and other bioactive moleculars could be synthesized through these methods. As one of the most important diazo compounds α-diazophosphonates could also proceed various chemical transformations and be used to synthesize varieties of organic functional phosphorous compounds. Because organic phosphorous compounds exhibit extensive bioactivities and pharmaceutic activities, the research of α-diazophosphonates has attracted lots of attentions of scientists. The recent development of the reactions of α-diazophosphonates catalyzed by various kinds of catalysts is summarized.

Key words: diazo compound, α-diazophosphonate, reaction property