Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (2): 503-507.DOI: 10.6023/cjoc201612005 Previous Articles     Next Articles

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盐酸黄连素的汇聚式合成研究

陈程a, 徐蒙蒙a, 赵青b, 刘承秀c, 杨鸿均a, 冯豫川a   

  1. a 西南民族大学化学与环境保护工程学院 成都 610041;
    b 西南民族大学预科教育学院 成都 610041;
    c 西南民族大学校医院 成都 610041
  • 收稿日期:2016-12-02 修回日期:2017-01-01 出版日期:2017-02-25 发布日期:2017-01-17
  • 通讯作者: 杨鸿均, 冯豫川 E-mail:yanghj@swun.cn
  • 基金资助:

    西南民族大学研究生创新(No.CX2015SZ045)和四川省教育厅(No.15ZB0487)资助项目.

A Concisely Convergent Synthesis of Berberine Chloride

Chen Chenga, Xu Mengmenga, Zhao Qingb, Liu Chengxiuc, Yang Hongjuna, Feng Yuchuana   

  1. a College of Chemistry & Environment Protection Engineering, Southwest University for Nationalities, Chengdu 610041;
    b Preparatory School, Southwest University for Nationalities, Chengdu 610041;
    c Southwest University for Nationalities Hospital, Chengdu 610041
  • Received:2016-12-02 Revised:2017-01-01 Online:2017-02-25 Published:2017-01-17
  • Supported by:

    Project supported by the Graduate Innovative Research Projects of Central Universities, Southwest University for Nationalities (No. CX2015SZ045) and the Research Projects Sichuan Provincial Department of Education (No. 15ZB0487).

The berberine chloride was synthesized starting from benzo[d][1,3]dioxole with the mild condition and the simple operation in overall 33% yield. The route includes the five steps of nucleophilic ring opening, deprotection and cyclization and so on. All intermediates were determined by 1H NMR, 13C NMR and MS techniques.

Key words: berberine chloride, convergent synthesis, benzo[d][1,3]dioxole, grignard regent