Rapid and Efficient Ultrasound-Assisted Method for the Synthesis of 2-Thioxo-2H-thiopyran and 2-Amino-6-thioxodihydropyridine Derivatives

doi:10.6023/cjoc201608017

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (2): 508-513.DOI: 10.6023/cjoc201608017 Previous Articles Next Articles

NOTE

超声辐射下2-硫代羰基-2H-噻喃和2-氨基-6-硫代羰基二氢吡啶衍生物的高效合成

林伟^a, 郑永祥^b, 黄志斌^b, 史达清^b

a 江苏理工学院化学与环境工程学院常州 213001;
b 苏州大学材料与化学化工学部苏州 215123

收稿日期:2016-08-22 修回日期:2016-11-02 发布日期:2016-11-17
通讯作者: 史达清 E-mail:dqshi@suda.edu.cn
基金资助:
国家自然科学基金（No.21502074）和江苏省高校自然科学重大研究（No.15KJA150006）资助项目.

Rapid and Efficient Ultrasound-Assisted Method for the Synthesis of 2-Thioxo-2H-thiopyran and 2-Amino-6-thioxodihydropyridine Derivatives

Lin Wei^a, Zheng Yongxiang^b, Huang Zhibin^b, Shi Daqing^b

a School of Chemistry and Environmental Engineering, Jiangsu Technology of University, Changzhou 213001;
b College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123

Received:2016-08-22 Revised:2016-11-02 Published:2016-11-17
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21502074) and the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions (No. 15KJA150006).

1. Rapid and Efficient Ultrasound-Assisted Method for the Synthesis of 2-Thioxo-2H-thiopyran and 2-Amino-6-thioxodihydropyridine Derivatives.PDF(768KB)

Abstract

A rapid and efficient ultrasound-assisted method for the synthesis of 2-thioxo-2H-thiopyran and 2-amino-6-thioxodihydropyridine derivatives by the reaction of 2-(1-phenylethylidene)malononitrile and carbon disulfide or isothiocy-anatobenzene catalyzed by NaOH has been developed. This protocol has the advantages of simple operation, short reaction times, high yields, and environmental friendliness. The structures of all the products were characterized by ¹H NMR, ¹³C NMR, IR and MS techniques. The reported method is the efficient approach for the synthesis of 2-thioxo-2H-thiopyran and 2-amino-6-thi-oxodihydropyridine derivatives.

Key words: 2-thioxo-2H-thiopyran, 2-amino-6-thioxodihydropyridine, ultrasound-assisted, synthesis

Cite this article

Lin Wei, Zheng Yongxiang, Huang Zhibin, Shi Daqing. Rapid and Efficient Ultrasound-Assisted Method for the Synthesis of 2-Thioxo-2H-thiopyran and 2-Amino-6-thioxodihydropyridine Derivatives[J]. Chin. J. Org. Chem., 2017, 37(2): 508-513.

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超声辐射下2-硫代羰基-2H-噻喃和2-氨基-6-硫代羰基二氢吡啶衍生物的高效合成

Rapid and Efficient Ultrasound-Assisted Method for the Synthesis of 2-Thioxo-2H-thiopyran and 2-Amino-6-thioxodihydropyridine Derivatives

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