Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (7): 1837-1841.DOI: 10.6023/cjoc201801047 Previous Articles     Next Articles



卢粤, 姜国芳, 谢宗波, 陈国庆, 乐长高   

  1. 东华理工大学应用化学系 南昌 330013
  • 收稿日期:2018-01-30 修回日期:2018-03-17 发布日期:2018-04-04
  • 通讯作者: 姜国芳, 乐长高;
  • 基金资助:


Synthesis of 2-Aminothiophene Derivatives Catalyzed by Amano Lipase M from Mucor javanicus

Lu Yue, Jiang Guofang, Xie Zongbo, Chen Guoqing, Le Zhanggao   

  1. Department of Applied Chemistry, East China University of Technology, Nanchang 330013
  • Received:2018-01-30 Revised:2018-03-17 Published:2018-04-04
  • Contact: 10.6023/cjoc201801047;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21462001, 21262002, 21465002), the Science and Technology Projects of Jiangxi Province (No. 20161BCB24006), the Science and Technology Foundation of the Jiangxi Provincial Education Department (Nos. KJLD14050, GJJ150584).

A series of 2-aminothiophene derivatives were synthesized by the Gewald reaction between α-active methylene nitrilthes and 2,5-dihydroxy-1,4-dithiane using amano lipase M from Mucor javanicus as biocatalyst. The method has the advantages of mild reaction conditions, biodegradability of catalyst and wide range of substrates compared with traditional catalysts.

Key words: α-active methylene nitrile, 2,5-dihydroxy-1,4-dithiane, lipase, Gewald reaction, 2-aminothiophene