Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (10): 2713-2719.DOI: 10.6023/cjoc201803006 Previous Articles     Next Articles



张薇a, 姚子健a, 邓维a,b   

  1. a 上海大学材料科学与工程学院 上海 200444;
    b 上海应用技术大学化学与环境工程学院 上海 201418
  • 收稿日期:2018-03-05 修回日期:2018-05-30 发布日期:2018-06-15
  • 通讯作者: 邓维,
  • 基金资助:


Poly (amido amine)s with Different Branched Architecture: Synthesis, Reactivity and Their Application in Gene Delivery

Zhang Weia, Yao Zijiana, Deng Weia,b   

  1. a School of Materials Science and Engineering, Shanghai University, Shanghai 200444;
    b School of Chemical and Engineering, Shanghai Institute of Technology, Shanghai 201418
  • Received:2018-03-05 Revised:2018-05-30 Published:2018-06-15
  • Contact: 10.6023/cjoc201803006
  • Supported by:

    Project supported by the Key Subject of Shanghai Municipal Education Commission (No. J50704) and the Natural Science Foundation of Shanghai City (No. 16ZR1435700).

Poly (amido amine)s with diverse topographical structures are promising candidates for gene delivery and drug carriers. A series of poly (amido amine)s (PAAs) with the same repeating units, however, different degree of branching, were successfully prepared by Michael addition polycondensation of N,N-methylenebis (acrylamide) (MBA) and L-cysteine methyl ester hydrochloride (CYS) in a water/dimethyl sulfoxide co-solvent. The obtained disposed cationic PAAs exhibit good DNA condensation capacities.

Key words: poly(amido amine)s, branched polymer, gene delivery, L-cysteine methyl ester hydrochloride, cyclodextrin