Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (3): 842-847.DOI: 10.6023/cjoc201809019 Previous Articles     Next Articles



黄金昌a, 雷春a, 阿吉艾克拜尔·艾萨b, 俞媚华a, 阿布力米提·伊力b, 侯爱君a   

  1. a 复旦大学药学院 生药学教研室 上海 201203;
    b 中国科学院新疆理化技术研究所 中国科学院干旱区植物资源化学重点实验室 新疆特有药用资源利用重点实验室 乌鲁木齐 830011
  • 收稿日期:2018-09-12 修回日期:2018-10-19 发布日期:2018-11-26
  • 通讯作者: 阿布力米提·伊力, 侯爱君;
  • 基金资助:


Isosteroidal Alkaloids from Fritillaria karelinii

Huang Jinchanga, Lei Chuna, Aisa Haji Akberb, Yu Meihuaa, Yili Abulimitib, Hou Aijuna   

  1. a Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203;
    b Key Laboratory of Plant Resources and Chemistry in Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011
  • Received:2018-09-12 Revised:2018-10-19 Published:2018-11-26
  • Contact: 10.6023/cjoc201809019;
  • Supported by:

    Project supported by the National Natural Science Foundation of China and the People's Government of Xinjiang Uygur Autonomous Region (NSFC-Xinjiang Joint Fund, No. U1403201).

Three new isosteroidal alkaloids, karelinine (1), 5-epikarelinine (2), and 27-epiebeienine (3), were isolated from the bulbs of Fritillaria karelinii by column chromatography and semipreparative HPLC (high performance liquid chro-matography), together with three known ones, ebeienine (4), persicanidine B (5), and heilonine (6). Their structures were identified by MS, 1D/2D NMR, and single-crystal X-ray diffraction. Compound 1 is a 5β-jervine isosteroidal alkaloid featuring a cis-fused A/B ring moiety, rarely found in the Fritillaria genus. Compounds 1 and 2 also represent the first jervine alkaloids with a 15 α-hydroxy group from this genus.

Key words: Fritillaria karelinii, isosteroidal alkaloids, karelinine, 5-epikarelinine, 27-epiebeienine