Synthesis and Insecticidal Activity of Novel Piperidine Thiazole Compounds

doi:10.6023/cjoc201809009

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (3): 836-841.DOI: 10.6023/cjoc201809009 Previous Articles Next Articles

Notes

新型哌啶噻唑类化合物的合成及杀虫活性

丁成荣, 潘亚运, 殷许, 谭成侠, 张国富

浙江工业大学杭州 310032

收稿日期:2018-09-05 修回日期:2018-10-22 发布日期:2018-11-26
通讯作者: 谭成侠, 张国富 E-mail:tanchengxia@zjut.edu.cn;gfzhang@zjut.edu.cn
基金资助:
浙江省绿色农药2011协同创新中心开放基金资助项目.

Synthesis and Insecticidal Activity of Novel Piperidine Thiazole Compounds

Ding Chengrong, Pan Yayun, Yin Xu, Tan Chengxia, Zhang Guofu

College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310032

Received:2018-09-05 Revised:2018-10-22 Published:2018-11-26
Contact: 10.6023/cjoc201809009 E-mail:tanchengxia@zjut.edu.cn;gfzhang@zjut.edu.cn
Supported by:
Project supported by the Collaborative Innovation Center of Zhejiang Province Green Pesticide.

1. Synthesis and Insecticidal Activity of Novel Piperidine Thiazole Compounds.PDF(5131KB)

Abstract

Twelve new piperdine thiazole compounds were designed and synthesized in search of new bioactive compounds. The preliminary bioassay showed that at the concentration of 500 μg/mL the lethal rates of the target compounds possessed certain insceticidal activities against armyworm, and at the concentration of 100 μg/mL the lethal rates of (4-(5-(3-chloro-phenyl) -4-methylthiazol-2-yl) piperidin-1-yl) (4-methylpiperazin-1-yl) methanone (1f) and (4-(5-(4-chlorophenyl) -4-methyl-thiazol-2-yl) piperidin-1-yl) nitro-1H-pyrazol-3-yl) methanone (1g) against armyworm were 80% and 100%, respectively. Further screening at concentrations of 20 μg/mL, the lethal rate of (4-(5-(4-chlorophenyl) -4-methylthiazol-2-yl) piperidin-1-yl) (4-nitro-1H-pyrazol-3-yl) methanone (1g) against armyworm was 50%.

Key words: oxathiapiprolin, piperidine-thiazolederivatives, insecticidal activity

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Ding Chengrong, Pan Yayun, Yin Xu, Tan Chengxia, Zhang Guofu. Synthesis and Insecticidal Activity of Novel Piperidine Thiazole Compounds[J]. Chin. J. Org. Chem., 2019, 39(3): 836-841.

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新型哌啶噻唑类化合物的合成及杀虫活性

Synthesis and Insecticidal Activity of Novel Piperidine Thiazole Compounds

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