Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (6): 2310-2318.DOI: 10.6023/cjoc202010010 Previous Articles     Next Articles



刘巨艳*(), 赵聪颖   

  1. 天津师范大学化学学院 天津市功能分子结构与性能重点实验室 天津 300387
  • 收稿日期:2020-10-09 修回日期:2020-12-28 发布日期:2021-03-25
  • 通讯作者: 刘巨艳
  • 基金资助:
    天津市自然科学基金(12JCZDJC34300); 大学生创业训练(201447)

Lactic Acid-Catalyzed Transamidation Reactions of Carboxamides with Amines

Juyan Liu(), Congying Zhao   

  1. Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387
  • Received:2020-10-09 Revised:2020-12-28 Published:2021-03-25
  • Contact: Juyan Liu
  • Supported by:
    Natural Science Foundation of Tianjin City(12JCZDJC34300); College Studentsʼ Entrepreneurship Training Program(201447)

An environmentally benign protocol for the transamidation of carboxamides with amines using lactic acid as a green catalyst has been developed. The method has been successfully applied to the synthesis of a wide range of aromatic and aliphatic amides and ureas. The reaction has the advantages of the ready accessibility of the catalyst, solvent-free condition, efficient transformation and green processing.

Key words: lactic acid, carboxamide, urea, transamidation