功能化金属-有机框架材料在肿瘤治疗中的研究进展

doi:10.6023/A19070259

化学学报 ›› 2019, Vol. 77 ›› Issue (11): 1156-1163.DOI: 10.6023/A19070259 上一篇下一篇

所属专题：多孔材料：金属有机框架(MOF)

综述

功能化金属-有机框架材料在肿瘤治疗中的研究进展

曾锦跃^a, 王小双^a, 张先正^a^b*(), 卓仁禧^a

^a 武汉大学化学与分子科学学院生物医用高分子材料教育部重点实验室武汉 430072
^b 武汉大学高等研究院武汉 430072

投稿日期:2019-07-11 发布日期:2019-09-09
通讯作者: 张先正 E-mail:xz-zhang@whu.edu.cn
作者简介:曾锦跃, 于2018年在武汉大学获得博士学位. 2018年至今在武汉大学生物医用高分子材料教育部重点实验室从事博士后研究. 主要研究兴趣是多孔晶态框架材料|王小双, 于2016年在武汉大学获得理学学士学位, 现为武汉大学化学与分子科学学院在读博士研究生. 研究方向是纳米材料的制备与功能化修饰及其在抗肿瘤领域的应用|张先正, 武汉大学教授、博士生导师. 1994、1997、2000年相继于武汉大学获学士、硕士和博士学位. 2000年9月～2001年8月新加坡材料研究所Research Associate. 2001年9月～2004年8月美国康奈尔大学博士后. 自2004年9月起在武汉大学化学与分子科学学院任教授, 主要从事生物医用高分子的研究|卓仁禧, 武汉大学教授、博士生导师. 主要从事生物医用高分子的研究
基金资助:
中国博士后科学基金(2019TQ234);中国博士后科学基金(2019M652693);国家自然科学基金(51833007);国家自然科学基金(51690152)

Research Progress in Functional Metal-Organic Frameworks for Tumor Therapy

Zeng Jinyue^a, Wang Xiaoshuang^a, Zhang Xianzheng^a^b*(), Zhuo Renxi^a

^a Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072
^b Institute for Advanced Studies, Wuhan University, Wuhan 430072

Received:2019-07-11 Published:2019-09-09
Contact: Zhang Xianzheng E-mail:xz-zhang@whu.edu.cn
Supported by:
the China Postdoctoral Science Foundation(2019TQ234);the China Postdoctoral Science Foundation(2019M652693);the National Natural Science Foundation of China(51833007);the National Natural Science Foundation of China(51690152)

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摘要/Abstract

恶性肿瘤由于其易转移、复发等特点，已经严重危害到人类的生命健康.近年来，研究人员设计了大量纳米药物载体，将抗肿瘤药物安全有效地运载到肿瘤，有效地提高了药效并降低了毒副作用.金属有机框架材料（metal-organic frameworks，MOFs）是一类有序、多孔的晶态材料，具有比表面积大、结构可设计性强、易生物降解等独特优势，已经被广泛应用于气体吸附与分离、催化、药物传递、生物大分子固载以及肿瘤治疗等方面.目前，基于MOFs的生物医用研究主要集中在MOF材料的可控合成，表面修饰，基于MOF独特理化性质发展的多模式成像技术以及肿瘤靶向的药物运载技术等几个方面.主要介绍了基于MOFs构建的生物功能化材料在肿瘤治疗中的应用，并对其在生物医学领域的应用进行了展望.

关键词: 金属-有机框架材料, 生物功能化, 纳米药物载体, 药物运载, 肿瘤治疗

Malignant tumor is considered to be one of the most threatening diseases to human health because it is easy to metastasis and relapse, hard to cure with high mortality. Construction of anti-tumor drug delivery systems would effectively improve the therapeutic efficiency of traditional tumor therapy agents. However, the complicated tumor micro-environment as well as the individual diversity of tumor would lead to low efficiency or treatment failure. The conventional tumor treatments, such as chemotherapy, radiotherapy and surgery, have been unable to satisfy the demand for tumor therapy owing to the severe side effect and low therapeutic efficiency. In recent years, researchers have designed a lot of multifunctional nano-drug carriers for efficient tumor therapy with reduced side effects. Metal-organic frameworks (MOFs), a class of ordered porous crystal materials, have received significant research attention for their applications in gas adsorption and separation, catalysis, drug delivery, immobilized bio-macromolecules and tumor therapy. Due to tunable inorganic building blocks and organic linkers, MOFs can not only integrate drugs or photosensitizers into periodic arrays, but also possess large pore sizes and high surface areas for drug encapsulation. Currently, the biomedical research of MOFs mainly includes the preparation of multifunctional biocompatible nanomaterials through controllable synthesis and reasonable surface modification. MOFs based nanomaterials with desired physiological functions have been widely used for targeting tumor imaging and therapy by utilizing their unique physical and chemical properties. The recent progress on the bio-functionalization of MOFs, including new design strategies and application in tumor therapy is summarized. Particularly, the construction of MOF-based nanoplatforms for tumor therapy on the basis of biomedical polymer modified MOFs is also described in detail. The development trends of MOFs for biomedical application are also prospected. We believe that this work will offer a preliminary understanding to design MOF-based drug delivery systems and acquire the therapeutic strategies of MOF-based nano-medicine for future clinical biomedical applications.

Key words: metal-organic frameworks, bio-functionalization, nano-drug carrier, drug delivery, tumor therapy

引用此文

曾锦跃, 王小双, 张先正, 卓仁禧. 功能化金属-有机框架材料在肿瘤治疗中的研究进展[J]. 化学学报, 2019, 77(11): 1156-1163.

Zeng Jinyue, Wang Xiaoshuang, Zhang Xianzheng, Zhuo Renxi. Research Progress in Functional Metal-Organic Frameworks for Tumor Therapy[J]. Acta Chimica Sinica, 2019, 77(11): 1156-1163.

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图/表 7

图 1. 基于金属-有机框架结构的生物功能化材料在肿瘤治疗中的应用

Figure 1. Bio-functionalization of metal-organic frameworks for tumor therapy

图 2. 卟啉MOFs纳米平台通过干扰乳酸消耗的呼吸作用用于增强PDT

Figure 2. Schematic illustration of porphyrinic MOFs nanoplatform for enhanced photodynamic therapy by interfering with the lactate-fueled respiration (Reproduced with permission.[19] Copyright 2018, Wiley-VCH)

图 3. 基于卟啉MOFs构建的核壳纳米材料(Pda-Pt@PCN-FA)的制备及纳米工厂工作过程

图 4. 聚乙二醇修饰的共轭延伸MOFs(TBP-MOF)用于肿瘤转移的抑制

图 5. 卟啉MOFs纳米系统用于一氧化氮产生和敏化PDT

图 6. 源自树突状细胞和肿瘤细胞的融合细胞的细胞膜包覆纳米光敏剂用于肿瘤的联合治疗

图 7. 超级中性粒细胞的仿生合成、体内的酶促催化反应过程、产生次氯酸的机理反应以及多样化的生物医用潜力

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功能化金属-有机框架材料在肿瘤治疗中的研究进展

Research Progress in Functional Metal-Organic Frameworks for Tumor Therapy

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