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化学学报
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化学学报 ›› 1955, Vol. 21 ›› Issue (2): 151-158. 上一篇    下一篇

论文

金微素的化学Ⅲ.金微素降解物的脱氯反应

黄耀曾, 盛怀禹, 冯识民, 徐元耀, 涂通源   

  1. 中国科学院有机化学研究所
  • 投稿日期:1955-02-08 发布日期:2013-06-04

STUDIES ON THE CHEMISTRY OF AUREOMYCIN Ⅲ. DECHLORINATION OF THE DEGRADATION PRODUCTS OF AUREOMYCIN

HUANG YAO-TSENG, YAO-TSENG HUANG   

  1. Institute of Organic Chemistry, Academia Sinica
  • Received:1955-02-08 Published:2013-06-04

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被引次数

3

脫二甲胺金黴素(Ⅳ),脫二甲胺脫羥金黴素(Ⅴ)分别予以接觸氫化,產生脫氯脫二甲胺金黴素(Ⅶ)及脫氯脫二甲胺脫羥金黴素(Ⅷ)。這兩種產物再分別以甲醇鹽酸處理,得到它們相當的脫水化合物:脫氯脫二甲胺脫水金黴素(Ⅹ)及脫氯脫二甲胺脫羥脫水金黴素(Ⅺ)。脫水金黴素(Ⅵ)經接觸氫化。產生脫氯脫水金黴素(Ⅸ)。後者用鋅粉醋酸氫解,亦得到Ⅹ與Ⅺ。

Desdimethylaminoaureomycin (IV) and desdimethylaminodesoxyaureomycin (Ⅴ), when subjected to catalytic hydrogenation, yield deschlorodesdimethylaminoaureomycin (Ⅶ) and deschlorodesdimethylaminodesoxyaureomycin (Ⅷ) respectively. On warming with methanolic hydrogen chloride, Ⅶ and VIII give their corresponding anhydro-compounds: deschlorodesdimethylaminoanhydroaureomycin (Ⅹ) and deschlorodesdimethylaminodesoxy-anhydroaureomycin (Ⅺ).