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化学学报
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化学学报 ›› 1955, Vol. 21 ›› Issue (2): 159-167. 上一篇    下一篇

论文

雨种α-(2-吡啶基)-β-烷基吲哚及数种β-咔卟啉衍生物的合成

高怡生   

  1. 中国科学院药物研究所 上海
  • 投稿日期:1955-02-25 发布日期:2013-06-04

SYNTHESIS OF TWO a-(2-PYRIDYL)-β-ALKYLINDOLES AND SOME β-CARBOLINE DERIVATIVES

KAO YEE-SHENG   

  1. Institute of Materia Medica, Academia Sinica
  • Received:1955-02-25 Published:2013-06-04

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1.合成了兩種吲(口朶)衍生物:α-(2-吡啶基)-β-甲基吲(口朶)及α-(2-吡啶基)-β-乙基吲(口朶)。前者的紫外線吸收光譜與阿爾斯泰令(alstyrine,係一種由西阿斯木鹼經硒降解後的產物)的吸收光譜極為類似;且二者有一種相同的顏色反應。因此說明阿爾斯泰令的結構可能與可利南斯令(corynanthyrine),α-[2-(4,5-雙乙吡啶基)]-β-乙基吲(口朶)相同。2.合成了三種β-咔卟啉的衍生物:2-環己烷甲基-β-咔卟啉,2-[(4'-甲基環己烷)甲基]-β-咔卟啉及2-[(2'-甲基環已烷)甲基]-β-咔卟啉。這些化合物的化學及物理性質都和阿爾斯泰令不同。因此後者不是β-咔卟啉衍生物。

Karrer and Enslin[2] reported that the structure of alstyrine (S19H22N2), a selenium-dehydrogenation-degradation product obtained by Sharphl from the alkaloid alstonine, is identical with that of corynanthyrine, a-(2-(4, 5 diethylpyridyl)]-β-ethylindole (Ⅱ), despite the fact that the melting points of these two substances have a 50 difference. In his investigation, the author of the present paper has synthesized two homologues of (Ⅱ), a-(2-pyridyl)-β-methylindole (Ⅲ) and a-(2-pyridyl)-β-ethylindole (Ⅳ), finding that the former has almost