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化学学报
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化学学报 ›› 1956, Vol. 22 ›› Issue (6): 581-584. 上一篇    下一篇

研究简报

不饱和胆酸一类物中的消除反应

黄鸣龙, 陶正娥   

  1. 医学科学院化学系
  • 投稿日期:1956-08-02 发布日期:2013-06-03

ELIMINATION REACTION IN THE UNSATURATED BILE ACID SERIES

HUANG MINLON(HUANG-MINLON), TAO CHENG-NGO   

  1. Department of Chemistry, Institute of Medical Sciences
  • Received:1956-08-02 Published:2013-06-03

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在研究将Cortisone及其他副肾皮素合成方法简便化及经济化过程中,我们想将12酮簇不饱和胆酸化合物(Ⅰ)[1]的C3上乙酯簇水解成羟基,以便于形成3,9-氧桥。结果证明,如用浓盐酸及甲醇处理,放置过夜,C3—OAc确能平滑地局部水解,生成Ⅱ[2]。并且即使放置一周,亦只有C3—OAc局部水解,而C7—OAc则不变。

The 12-keto compound (Ⅰ) was transformed through the hydrolysis of the C3-OAc and the elimination of acetosyl group at C7 into compound(Ⅲ) by methanolic hydrogen chloride.The mechanism of the elimination reaction is proposed.