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化学学报
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化学学报 ›› 1959, Vol. 25 ›› Issue (3): 146-151. 上一篇    下一篇

论文

α-甲基-β-烃基六氢吡啶的合成

于同隐1, 崔惠卿2, 黄鸣玉3   

  1. 1. 复旦大学化学系;
    2. 南京药学院;
    3. 第二军医大学药学系
  • 投稿日期:1958-03-21 发布日期:2013-06-03

SYNTHESES OF α-METHYL-β-ALKYLPIPERIDINES

YU TUNG-YIN1, TSWEI HUI-CHING2, HUANG MIN-YUH3   

  1. 1. Department of Chemistry, Fudan University;
    2. Department of Pharmacy, The 2nd Military Medical College
  • Received:1958-03-21 Published:2013-06-03

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695

被引次数

4

从α-烃基乙酰乙酸乙酯开始,经氰乙基代反应,再水解得相应的γ-氰基酮。酮用钠和丁醇还原环化行一系列的α-甲基-β-烃基六氢吡啶,还原的产率不高。主要的副产物是6-氨基己醇-2的3-烃基衍生物。α-烃基-α-氰乙甚乙酰乙酸乙酯的水解副产物——液体的γ-氰基酸,在加热时析出固体,这些固体证明是α-烃基戊二酰亚胺,系由相应的γ-氰基酸加热重排而成。这一反应可用于检定γ-氰基酸。

A aeries of α-mothyl-β-alkylpiperidinos were synthosizo:l in low yields by reductive cyclization of tho conosponding γ-cyanokotonoa with sodium and butyl alcohol.These cyanokotones were in turn preparod by cyanoothylation of α-allcyl-acetoacetic esters with subsequent kotonic liydrolysie.Tho chief by-products isolated were 6-amino-3-alkyl hexanol-2.