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化学学报
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化学学报 ›› 1960, Vol. 26 ›› Issue (2): 79-83. 上一篇    下一篇

论文

血吸虫病化学治疗的研究Ⅸ.——酚类化合物的Mannich硷

白东鲁, 嵇汝运   

  1. 中国科学院药物研究所
  • 投稿日期:1959-11-25 发布日期:2013-06-03

CHEMOTHERAPEUTIC STUDIES ON SCHISTOSOMIASIS Ⅸ.SOME MANNICH BASES DERIVED FROM SUBSTITUTED PHENOLS

BAI DONG-Lu, JI RU-YUN   

  1. Institute of Materia Medica, Academia Sinica, Shanghai
  • Received:1959-11-25 Published:2013-06-03

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对位有氯、溴、硝基、甲氧基、甲巯基、甲基、苯基等取代基的苯酚与甲醛及仲胺共热,或与双(二烃氨基)甲烷作用,生成预期的2-二烃氨甲基-4-取代基苯酚.以1,4-二氮六圜作为仲胺作用,酚、醛、胺的用量比虽为1:1:1,反应却以2:2:1的比例进行,获得N,N'-双(2-羟基芳甲基)-1,4-二氮六圜.3,4-二巯基甲苯与甲醛及仲胺作用时,氨甲基引进在硫原子上,生成3,4-双(二烃氨甲巯基)甲苯.

Organo-antimonyl derivatives are effective schistosomicides. Their mechanism may be d ae to the interaction between antimony and mercapto-containing enzymes in the parasites. Since it seems that Mannich bases, which are active alkylating agents, are also capable to fix the mercapto compounds, it would be interesting to see if certain Mannich bases were active against schistosomiasis. A number of Mannich bases have therefore been prepared from substituted phenols in the present woik.