化学学报 ›› 1962, Vol. 28 ›› Issue (4): 263-265. 上一篇    

研究简报

35标记化合物的合成——Ⅰ. 2, 3-二巰基丁二酸-S235

章辛, 杨正修   

  1. 中国科学院药物研究所
  • 投稿日期:1962-02-02 发布日期:2013-06-03

SYNTHESIS OF S35-LABELLED COMPOUNDS Ⅰ. 2, 3-DIMERCAPTOSUCCINIC ACID-S235

CHANG SING, YANG CHENG-HSIU   

  1. Institute of Materia Medica, Academia Sinica
  • Received:1962-02-02 Published:2013-06-03

本工作简化2, 3-二巯基丁二酸的合成步骤, 以半微量法制各其硫35标记的化合物(Ⅵ).此法操作步骤较为简便安全, 产品纯度及产率均满意.

2, 3-Dimercaptosuccinic acid-S235 has been synthesized as follows:Sodium sulphidc-S35(Ⅰ) was oxidized with iodine to give sulphur-S35(Ⅱ).The latter was converted into phosphorous pentasulphide-S535(Ⅲ) by the action of red phosphorous.Interaction of Ⅲ and acetic acid gave thiolacetic acid-S35(Ⅳ).2, 3-Bis-acetylthiosuccinic acid-S235(Ⅴ) was obtained by the addition of compound IV to acetylenedicarboxylic acid.Upun hydrolysis of V the desired 2, 3-dimercaptosuccinic acid-SZS(Ⅵ) was obtained.This method has been found to be satisfactory for the synthesis with the advantages of convenience and safety in handling.