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化学学报
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化学学报 ›› 1963, Vol. 29 ›› Issue (2): 133-142. 上一篇    下一篇

论文

含半胱氨酸多肽的研究Ⅰ.胰岛素A鏈中苄氧羰(S-苄基)半胱(S-苄基)半胱·丙·甘·纈·(S-苄基)半胱氨酸乙酯(A6-A11)**的合成

李崇熙, 陸德培, 張明哲, 伍少蘭, 邢其毅   

  1. 北京大学化学系有机化学教研室
  • 投稿日期:1962-09-27 发布日期:2013-06-03

CYSTEINE PEPTIDES Ⅰ. SYNTHESIS OF A PROTECTED HEXAPEPTIDE WITH THE AMINOACID SEQUENCE 6-11 OF THE A-CHAIN OF INSULIN

LI CHUNG-HSI, LOH TEH-PEI, CHANG MING-CHE, WU SHAO-LAN, HSING CHI-YI   

  1. Division of Organic Chemistry, Chemistry Department, Peking University
  • Received:1962-09-27 Published:2013-06-03

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本文报告胰岛素A键Cbz(S-Bz)Cys-Ala·Gly·Val·(S-Bz)Cys·O-Bz(A7-A11)五肽和Cbz(S-Bz)Cys·(S-Bz)Cys·Ala-Gly-Val·(S-Bz)Cys-OEt(A6-A11)六肽的合成。五肽是用活化酯方法,由Cbz(S-Bz)Cys-ONP与H·Ala-Gly·Val·(S-Bz)Cys·OBz(A3-A11)合成。将纯浄的Cbz(S-Bz)Cys-(S-Bz)Cys-OH和旋光纯的H·Ala·Gly·Val(S-Bz)Cys·OEt四肽,经混合酸酐和碳二亚胺两种方法接肽,获得熔点和比旋度完全一致的六肽。该六肽Cbz(S-Bz)Cys-(S-Bz)Cys·Ala·Gly·Val·(S-Bz)Cys·OEt(A6-A11)应为光学纯的化合物。

The syntheses of N-carbobenzoxy-S-benzyl-L-cysteinyl-L-alanyl-glycyl-L-valyl-S-benrylL-cysteine benzyl ester and N-carbobenzoxy-S-benryl-L-cysteinyl-S-benzyl-L-cysteinyl-Lalanyl-glycyl-L-valyl-S-benryl-L-cysteine ethyl ester are described.These are two peptides containing more than one cysteine unit with the amino-acid sequences(A7-A11) and (A6-A11) of the A chain of insulin.