化学学报 ›› 1964, Vol. 30 ›› Issue (2): 226-229. 上一篇    下一篇

研究简报

中药使君子化学成分的研究Ⅰ.使君子叶中化学成分的分离和鉴定

方圣鼎, 朱任宏   

  1. 中国科学院药物研究所
  • 投稿日期:1963-04-15 发布日期:2013-06-03

THE CHEMICAL CONSTITUENTS OF LEAVES OF SHIH-CHUN-TZE, QUISQUALIS INDICA L.

FANG SHENG-DIN, CHU JEN-HONG   

  1. Institute of Materia Medica, Academia Sinica
  • Received:1963-04-15 Published:2013-06-03

使君子(Quisqualis indica L.)为使君子科(Combretaceae)植物,产于我国西南各省.其果实用作驱蛔虫药,效果良好.李时珍[1]称“此药味甘气温,既能杀虫又益脾胃,所以能敛虚热,而止泻痢,为小儿诸病要药”.其中化学成分,柳田[2]曾得N-甲基烟酸内盐.赵承嘏[3]等得吡啶.陈思义等[4]得使君子酸钾(C10H16O10N6K3),并经药理[4]和临床试验[5]证实是驱蛔虫有效成分.

Four crystalline constituents have been isolated from the leaves of Shih-chun-tze,Quisqualis indica L.They are identified to be nicotinic acid methylbetaine (Trigonelline),L-proline,L-asparagine and potassium quisqualate by direct comparison of the physical constants including Rf values on paper strips of the compounds with those of the authentic samples.The original molecular formula of potassium quisqualate,C16H16O10N6K3,is revised to C5H6O5N3K,according to molecular weight determination of the quisqualic acid and of the potassium salt,as well as the analyses of its crystalline potassium salt and dinitrophenyl derivative.