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化学学报
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化学学报 ›› 1964, Vol. 30 ›› Issue (5): 509-512. 上一篇    下一篇

研究简报

几种5,5-取代的乙内酰脲之合成

葛怀誠, 蔣尚信   

  1. 上海第二医学院
  • 投稿日期:1963-10-29 修回日期:1964-05-20 发布日期:2013-06-03

THE SYNTHESIS OF SOME 5,5-SUBSTITUTED HYDANTOINS

KO HUEI-CHENG, CHIANG SHANG-SING   

  1. Shanghai Second Medical College
  • Received:1963-10-29 Revised:1964-05-20 Published:2013-06-03

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乙内酰脲衍生物广泛应用于α-氨基酸的合成中,若干5,5-取代乙内酰脲衍生物又用作抗惊厥、安眠及治疗癫痫的药物。

Some 3,4-dimethoxybenzyl ketones are prepared by the action of different acid anhydrides on homoveratric acid. From these ketones the following 5,5-substituted hydantoms are synthesized: 5-methyl-5-(3',4'-dimethoxybenzyl)-hydantoin, m.p. 240-1°;5-ethyl-5-(3',4'-dimethoxybenzyl)-hydantoin, m.p. 224-225.5°;and 5,5-di-(3',4'-dimethoxy-benzyl)-hydantoin, m.p. 293-4.5. The infrared spectra of the last two compounds are recorded.