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化学学报
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化学学报 ›› 1965, Vol. 31 ›› Issue (1): 64-71. 上一篇    下一篇

论文

肿瘤的化学治疗——ⅩⅫ.DL-N-二氯乙酰基-7-硝基色氨酸及其有关化合物的合成

翁尊尧   

  1. 中国科学院药物研究所
  • 投稿日期:1964-03-05 发布日期:2013-06-03

TUMOUR CHEMOTHERAPY ⅩⅫ. SYNTHESIS OF DL-N-DICHLOROACETYL-7-NITROTRYPTOPHAN AND RELATED COMPOUNDS

OWEN TSUNG-YAO   

  1. Institute of Materia Medica, Academia Sinica
  • Received:1964-03-05 Published:2013-06-03

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1.本文叙述以7-硝基吲哚(ⅩⅣ)为原料,合成DL-N-二氯乙酰基-7-硝基色氨酸(Ⅷ)及其乙酯(Ⅺ);从DL-色氨酸(Ⅰa)制备DL-N-二氯乙酰基色氨酸(Ⅶ).2.从7-硝基克胺(ⅩⅤ)合成7-硝基吲哚乙酸(Ⅹ)及其甲酯(ⅩⅢa)和乙酯(ⅩⅢb).3.化合物Ⅷ和Ⅺ对HeLa细胞有明显的抑制作用.

In this communication, the syntheses of DL-N-dichloroacetyl-7-nitrotryptophan (Ⅷ), its ethyl ester (ⅩⅠ), DL-7-nitrotryptophan hydrochloride (Ⅸ), its ethyl ester (ⅩⅡ), 7-nitro-indolylacetic acid (Ⅹ), and its methyl and ethyl esters (ⅩⅢ:and ⅩⅢ) and Ⅶ are reported.Moreover, Ⅱ was also prepared.