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化学学报
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化学学报 ›› 1966, Vol. 32 ›› Issue (1): 68-77. 上一篇    下一篇

论文

含半胱氨酸多肽的研究——Ⅲ.牛胰岛素A链带保护基的氨端九肽的合成

汪猷, 季爱雪, 陆德培, 李崇熙, 施溥涛, 叶蕴华, 汤卡罗, 邢其毅   

  1. 北京大学化学系
  • 投稿日期:1965-05-24 发布日期:2013-06-03

CYSTEINE PEPTIDES——Ⅲ. SYNTHESIS OF A PROTECTED N-TERMINAL NONAPEPTIDE OF THE A-CHAIN OF BOVINE INSULIN

WANG Yu, CHI Ai-Hsueh, LOH Teh-Pei, LI Chung-Hsi, SHI Pu-Tao, YIEH Yuen-Hwa, TANG Car-Lo, HSING Chi-Yi   

  1. Department of Chemistry, Peking University
  • Received:1965-05-24 Published:2013-06-03

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679

被引次数

4

苄氧羰基甘氨酰-异亮氨酚-缬氨酰-γ-叔丁酯谷氨酸乙醋(Ⅲ)分别由已知的苄氧羰基缬氨酰-γ-叔丁酯谷氨酸乙醋经催化氢解法脱去N-保护基后与苄氧羰基甘氨酰-异亮氨酰阱(Ⅷ)按迭氮化合物法缩合,以及由已知的苄氧羰基甘氨酰-异亮氨酰-缬氨酸(Ⅷ)与γ-叔丁酯谷氨酸乙醋按碳二亚胺法合成.

The synthesis of a protected N-terminal nonapeptide of the A-chain of bovine insulin N-carbobenzoxy-glycyl-L-leucyl-L-valyl-γ-t-butyl-glutaminyl-S-benzyl-L-cysteinyl-S-benzyl-L-cysteinyl-L-alanyl-O-acetyl-L-serine (Ⅱa) and its methyl ester (Ⅰ) and hydrazide (Ⅱ) are described.