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化学学报
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化学学报 ›› 1975, Vol. 33 ›› Issue (1): 75-78. 上一篇    下一篇

论文

脱氧三尖杉酯碱及其类似物的研究

李述文, 戴金媛   

  1. 上海药物研究所
  • 投稿日期:1974-08-16 发布日期:2013-06-03

A STUDY ON THE DEOXYHARRINGTONINE AND ITS ANALOGUES

LI SHU-WEN, DAI JIN-YUAN   

  1. Shanghai Institute of Materia Medica
  • Received:1974-08-16 Published:2013-06-03

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506

被引次数

7

由三尖杉属植物中分离得到的脱氧三尖杉酯碱(Ⅰ)生物碱具有显著的抑制肿瘤P-388的作用.本文报导由α-酮酸(Ⅳ)与三尖杉碱(Ⅴ)经Reformatsky反应缩合而成脱氧三尖杉酯碱(Ⅰ).用同样方法制得脱氧三尖杉酯碱(Ⅰ)的类似化合物Ⅱ、Ⅲ.

Deoxyharringtonine (Ⅰ) isolated from Cephalotazzcs plant material is known as an alkaloid with significant inhibitory activity against P-388 leukemia.We now report the synthesis of deoxyharringtonine (Ⅰ) by condensation of a-ketoacid (Ⅳ) with cephalotaxine (Ⅴ) through a Reformatsky reaction.The analogues (Ⅱ,Ⅲ)of deoxyharringtonine (Ⅰ) have been synthesized by the same procedure.