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化学学报
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化学学报 ›› 1976, Vol. 34 ›› Issue (2): 149-152. 上一篇    

研究简报

dl—前列腺素F2a的合成

前列腺素合成组   

  1. 中国科学院上海有机化学研究所
  • 投稿日期:1975-11-13 发布日期:2013-06-03

THE SYNTHESES OF dl-PROSTAGLANDIN F2a

THE PROSTAGLANDIN SYNTHESIS GROUP Shanghai   

  1. Institute of Organic Chemistry, Academia Sinica
  • Received:1975-11-13 Published:2013-06-03

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前列腺素是具有广泛生物活性的一类天然物质[1,2a,b]。几年来的临床试验已经证明,用前列腺素于催产、流产效果是显著的,用于抗早孕也是有希望的[2a,b]。为了研制计划生育用的新药,我们开展了前列腺素及其类似物的合成。

dl-Prostaglandin F2α(Ⅹ) was synthesized from cyclopentadiene via a ten-step process.dl-Diol(Ⅱa) was epoxidized sterospecifically by peraoids to the dl-epozide(Ⅲa),the structure of whioh was established by oxidation to the known compound (ⅩⅤ).However,the diacetate(Ⅱb) reaoted with peracids to give a 1:1 mixture of cis-syn-cis and cis-anti-cis dl-isomers (Ⅲb) and (ⅩⅡ).