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化学学报
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化学学报 ›› 1976, Vol. 34 ›› Issue (4): 283-293. 上一篇    下一篇

论文

海南粗榧抗肿瘤有效成分的研究

  

  1. 1. 中国医学科学院药物研究所;
    2. 中国人民解放军第一八七医院
  • 投稿日期:1976-07-09 发布日期:2013-06-03

STUDIES ON THE ANTITUMOR CONSTITUENTS OF CEPHALOTAXUS HAINANENSIS LI.

  1. 1. INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES;
    2. THE 187TH HOSPITAL OF CHINESE PEOPLE'S LIBERATION ARMY
  • Received:1976-07-09 Published:2013-06-03

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自海南粗榧树皮中共分离出11种生物碱,其中9种生物碱经鉴定分别为脱氧三尖杉酯碱(Ⅰ)、异三尖杉酯碱(Ⅱ)、三尖杉酯碱(Ⅲ)、高三尖杉酯碱(Ⅳ)、三尖杉碱(Ⅴ)、桥氧三尖杉碱(Ⅵ)、脱甲基三尖杉酮碱(Ⅶ)、3-表西哈灭里辛碱(Ⅷ)、表三尖杉碱(Ⅺ),碱Ⅸ为一种新生物碱,碱Ⅹ的结构尚待进一步研究.动物试验结果表明碱Ⅰ、Ⅱ、Ⅲ和Ⅳ能延长白血病小鼠L615的生命,碱Ⅴ、Ⅵ、Ⅶ和Ⅹ则无明显活性.碱Ⅰ、Ⅱ、Ⅲ和Ⅳ已经临床试用,初步观察到碱Ⅲ对急性和慢性粒细胞白血病有一定疗效.碱Ⅰ、Ⅱ和Ⅳ的疗效正在观察中.

Eleven alkaloids were isolated from the bark of Cephalotaxus hainanensis Li.Nine of them were identified as deogyharringtonine (Ⅰ),isoharringtonine (Ⅲ), harringtonine (Ⅲ),homoharringtonino (Ⅳ),cephalotaxine (Ⅴ),drupaoine (Ⅵ), desmethyloephalotaginone (Ⅶ),3-epischelhammericine (Ⅷ) and epioephalotaxine (ⅩⅠ),respectively. The struoture of alkaloid Ⅸ, a neiv alkaloid, was postulated on the bases of its spectrometric data as the epimer of "phelline alkaloid 6". Alkaloid X has not yet been characterized due to scarcity of material.