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化学学报
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化学学报 ›› 1978, Vol. 36 ›› Issue (4): 283-289. 上一篇    下一篇

论文

胡椒酮类似物的合成研究

黄天俊1, 张似蓉1, 庄成钧2   

  1. 1. 四川省绵阳地区药品检验、中草药研究所;
    2. 安县人民医院
  • 投稿日期:1977-03-30 发布日期:2013-06-03

SYNTHSIS OF PIPERITONE RELATED COMPOUNDS

HUANG TIAN-JUN1, CHANG SI-RONG1, CHUANG CHENG-CHUN2   

  1. 1. Institute of Chinese Herb Medicine and Drug Censoring of Mian-Yang District, Szechwan Province;
    2. An Sien People's Hospital
  • Received:1977-03-30 Published:2013-06-03

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合成了胡椒酮的衍生物和类似物16种,连同选用的市售药物和试剂4种进行了解痉活性的筛选。初步的临床观察表明消旋1,1'-双异薄荷酮(5)对支气管痉挛的哮喘有较好的作用,研究了化学结构与解痉活性的关系。

Sixteen derivatives and analogs of piperitone were synthesized, and, together with four selected commercial drugs and reagents, were subjected to pharmacological screening in respect to their antispasmodic activity.Preliminary clinical observations show that racemio 1, 1'-bisisomenthone is quite effective against bronchospasmodic asthma.The correlation of chemical structure with antispasmodio activity was studied.