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化学学报
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化学学报 ›› 1980, Vol. 38 ›› Issue (5): 475-480. 上一篇    下一篇

论文

中国乌头之研究Ⅻ.宣威乌头中的生物碱及其结构研究

王洪诚1, 朱大珠2, 赵志远1, 朱任宏1   

  1. 1. 中国科学院上海药物研究所;
    2. 上海市药品检验所
  • 投稿日期:1978-10-25 发布日期:2013-06-03

STUDIES ON THE CHINESE DRUG, ACONITUM SPP Ⅻ.ALKALOIDS FROM XUAN-WU, ACONITUM NAGARUM STAPF VAR.LASIANDRUM W.T.WANG

WANG HONG-CHENG1, ZHU DA-ZHU2, ZHAO ZHI-YUAN1, ZHU REN-HONG1   

  1. Shanghai Institute of Materia Medica, Academia Sinica
  • Received:1978-10-25 Published:2013-06-03

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677

被引次数

19

从宣威乌头中分得四个二萜类生物碱,经光谱及化学方法研究,宣乌1即一枝蒿甲素,后者分子式应更正为C22H33O2N,它的结构正在研究中:宣乌2即一枝蒿庚素,后者分子式应更正为C22H31O3N,经鉴定为宋果灵(Songorine);宣乌3即一枝蒿乙素,经鉴定为尼奥灵(Neoline);宣乌4即一枝蒿丙素,它的结构证明为14-乙酰尼奥灵,为一新化合物.

Four crystalline alkaloids Xuan-Wu 1,2,3 and 4 have been isolatod from the root of Aconitum nagarum Stap var.lasiandrum W.T.Wang(a Chinose folk medicine).Xuan-Wu 1,2,3 and 4 are proved to be identical with Bullatine A,G,B and C respectively by comparison of their physical constants,1R,TLC and mixed melding points,Thoreforu,the molecular formula of Bullatine A ought to be amended to C22H33O2N and Bullatine G to C22H31O3N.Furthermore,Xuan-Wu 2 and 3 have been proved to be idantical with the known compounds songorine and neoline respectively and tha structure of Xuan-Wu 4(i.e.Bullatine C) is proved by chemical and speotral studies to be a new compound,14-acetylneolino.