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化学学报
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化学学报 ›› 1980, Vol. 38 ›› Issue (5): 502-505. 上一篇    下一篇

通讯

美登素全合成的研究Ⅰ.C1—C8片段的立体选择性合成

潘百川, 张红, 潘纯英, 舒韫, 王照福, 高怡生   

  1. 中国科学院上海药物研究所
  • 投稿日期:1979-08-18 发布日期:2013-06-03

STUDIES ON THE TOTAL SYNTHESES OF MAYTANSINOIDS Ⅰ.STEREOSELECTIVE SYNTHESIS OF C1—C8 FRAGMENT OF MAYTANSINE

PAN BAI-CHUAN, ZHANG HONG, PAN CHUN-YING, SHU YUN, WANG ZHAO-FU, GAO YI-SHENG   

  1. Shanghai Institute of Materia Medica, Academia Sinica, Shanghai
  • Received:1979-08-18 Published:2013-06-03

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美登素(Maytansine 1)系从美登木(Maytenus ovatus)中分得,极低剂量就对多种动物肿瘤有明显抑制作用.我国亦从云南美登木(Maytenus hookeri)中分得美登素.1是十九员柄型大环内酰胺,有八个手性碳原子和两个反式共轭双键,各国化学家对其全合成已作了许多工作.本文报道C1—C8片段2的合成.片段中包含五个手性碳原子,由核磁共振、反应机制等推断其绝对构型与美登素一致.

The antitumor ansa macrolide rnaytansine(1),isolated from Maytenus Ovatus,has attracted immense interests of organic ohemists in many countries.We wish to roport the stereoseleotive syntheses of the C1-C8 fragment with five ohiral centers in natural configuration.