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化学学报
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化学学报 ›› 1980, Vol. 38 ›› Issue (5): 507-510. 上一篇    

通讯

美登素全合成的研究Ⅱ.C9—N片段的合成

周启霆1, 白东鲁1, 孙菡丽1, 杨幼春2, 杜元华1, 徐仪宝1, 陈梅卿2, 高怡生1   

  1. 1. 中国科学院上海药物研究所;
    2. 上海第十二制药厂
  • 投稿日期:1979-08-18 发布日期:2013-06-03

STUDIES ON THE TOTAL SYNTHESES OF MAYTANSINOIDS Ⅱ.PREPARATION OF THE C9-N MOIETY

ZHOU QI-TING1, BAI DONG-LU1, SUN HAN-LI1, YANG YOU-CHUN2, DU YUAN-HUA1, Xu YI-BAO1, CHEN MEI-QING2, GAO YI-SHENG1   

  1. Shanghai Institute of Materia Medica, Academia Sinica
  • Received:1979-08-18 Published:2013-06-03

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前报报道了相当于美登素(1)C1—C8片段的化合物的合成,本文报道相当于美登素C9—N片段的化合物2的合成.

A compound 2 corresponding to C;,-N fragment of maytansine has been spnthe-sized.Starting from 2-methogy-(i-nitroaniline(3),4-Chloro-3-methoxy-5-methyl-aminobenzaldehyde(11) was prepared through sig steps,the position of bromine in 4 heing proved by means of NMR.