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化学学报
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化学学报 ›› 1981, Vol. 39 ›› Issue (4): 354-357. 上一篇    下一篇

研究简报

全氟2-甲基-3-氧杂戊二酸及其衍生物的合成

马敬骥, 徐以霜, 王九思, 黄耀曾   

  1. 中国科学院上海有机化学研究所
  • 投稿日期:1979-04-03 发布日期:2013-06-03

SYNTHESIS OF PERFLUORO-2-METHYL-3-OXA-GLUTARIC ACID AND ITS DERIVATIVES

MA JING-JI, XU YI-SHUANG, WANG JIU-SI, HUANG YAO-ZENG(HUANG YAO-TSENG)   

  1. Shanghai Institute of Organic Chemistry, Academia Sinica
  • Received:1979-04-03 Published:2013-06-03

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702

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2

Fritz等曾报道用草酰氟与全氟环氧丙烷反应制取全氟2-甲基-3-氧杂戊二酸(1)[1].本文报道全氟2-(2'-氟磺酰基乙氧基)丙酸用亚硫酸钠还原,使氟磺酰基转变成亚磺酸钠,再用氢溴酸除硫而得1的另一个方法.

Reduotion of perfluoro-2-(2'-fluorosulfonylethogy) propionic acid with sodium sulfite followed by treatment with hydrogen bromide gave perfluoro-2-methyl-3-oxa-glutaric acid. Its dimethyl ester on treating with NHS afforded a diamide (m. p. 162℃),which gave an imide (b. p. 65~68℃/2 mm) instead of a dinitrile on heating with P205. Perfluoro-2-methyl-3-ova-glutaric anhydride (b. p. 69~70℃) was prepared in the usual manner. Their structures were proved by IR, NMR and elemental analysis.