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化学学报
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化学学报 ›› 1981, Vol. 39 ›› Issue (4): 376-381. 上一篇    

通讯

螺旋构象的微环境效应——2.羧甲基糖淀粉钠对各种碘代N-烷基3-羟基吡啶羧酸酯水解的催化效应

惠永正, 顾建华, 蒋锡夔   

  1. 中国科学院上海有机化学研究所
  • 投稿日期:1980-06-11 修回日期:1981-01-24 发布日期:2013-06-03

THE MICROENVIRONMENTAL EFFECTS OF THE HELICAL CONFORMATIONS OF AMYLOSE AND ITS DERIVATIVES 2. CATALYTIC EFFECTS OF SODIUM CARBOXYMETHYLAMYLOSE ON THE HYDROLYSIS OF VARIOUS CARBOXYLIG ESTERS OF N-ALKYL-3-HYDROXYPYRIDINIUM IODIDE

HUI YONG-ZHENG, GU JIAN-HUA, JIANG XI-EUI(CHIANG HSI-KWEI)   

  1. Shanghai Institute of Organic Chemistry, Academia Sinica
  • Received:1980-06-11 Revised:1981-01-24 Published:2013-06-03

PDF

567

被引次数

14

前文[1]中我们已报道,糖淀粉[聚α-(1,4)D(+)-葡萄吡咯糖]的羧甲基钠盐(Na-CMA)(1)可与具有合适疏水基团的受物形成相当稳定的螺旋包结物结构,在包结过程中伴随着高分子链从线团至间断螺旋的构象变化.本文将报道如此形成的螺旋包结结构对催化酯水解反应所提供的特殊微环境效应.所用羧甲基糖淀粉钠[2]的数均分子量为6.27×104;置换度为0.41.受物为各种碘代N-烷基3-羟基吡啶羧酸酯2～5,乃自3-羟基吡啶与各相应的酸酐反应得到3-羟基吡啶羧酸酯,再与碘代烷反应而制备.

In a previous report we have shown that sodium carboxymethylamylose(Na-CMA, 1) can form relatively stable inclusion complexes with substrates possessing hydrocarbon chains of suitable length. The inclusion process is accompanied by conformational changes of the polymer chain of 1 from coils to interrupted helices. In this communication we report our first attempt to utilize this microenvironment provided by the helical conformations of 1 as a hydrolytic enzyme model; catalytic effects on the hydrolysis of various esters (2 to 5) are presented.