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化学学报
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化学学报 ›› 1982, Vol. 40 ›› Issue (5): 463-468. 上一篇    下一篇

研究简报

芳香胺参加的Mannich反应

徐秀娟, 陈光旭   

  1. 北京师范大学化学系
  • 投稿日期:1980-10-04 发布日期:2013-06-03
  • 通讯作者: 徐秀娟

ARYLAMINES AS THE AMINE COMPONENT IN MANNICH REACTIONS

XU XIU-JUAN, CHEN GUANG-XU   

  1. Department of Chemistry, Beijing Normal University
  • Received:1980-10-04 Published:2013-06-03

PDF

787

被引次数

119

Mannioh反应是一个在合成中多方面适用的反应.但许多人认为芳胺不能作为胺组分参加这个反应[1~4].Tramontini近期的综述[5]中提到芳胺参加Mannich反应的例子,其酸性组分均是酚类而非典型的酮类.Кулиев等[6]曾报道苯胺或其衍生物直接与酮的Mannich碱盐酸盐反应而生成β-芳胺基苯丙酮.

Mamnich reaotion ooours readily between aromatio primary amine, formaldehyde and alkylarylketono by the following method: arylamine was oondensod with formaldehyde in e-Lhanol at room temperature to form 3 or 5. On adding a solution of alkylarylketone in ethanolio HCl, β-arylaminoketone hydrochlorides were formed in high yields. This is a new method for direct synthesis of ,β-arylaminoketones through Mannic}h reaotion.