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化学学报
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化学学报 ›› 1982, Vol. 40 ›› Issue (6): 573-576. 上一篇    

通讯

7α和7β-甲基-10β, 17β-二乙酰氧基-⊿4-雌甾烯-3-酮的合成

倪元, 郝日英, 周维善   

  1. 中国科学院上海有机化学研究所
  • 投稿日期:1981-05-21 发布日期:2013-06-03
  • 通讯作者: 周维善

SYNTHESIS OF 7α-METHYL AND 7β-METHYL-10β, 17β-DIACETOXY-⊿4-ESTRENE-3-ONE

NI YUAN, HAO RI-YING, ZHOU WEI-SHAN   

  1. Shanghai Institute of Organic Chemistry, Academia Sinica
  • Received:1981-05-21 Published:2013-06-03

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文献报道炔诺酮类或17β-羟基(乙酰氧基)-⊿5(⊿4)-雌(雄)甾烯-3-酮类化合物中引入7α-甲基可增强其抗生育活性[1~3].我们曾合成10β-乙酰氧基-17β-羟基-17α-乙炔基-⊿4-雌甾烯-3-酮,经动物试验也显示较强的抗生育活性[4].

Since 7α-methyl or 10β-aoetogy steroidal ketones been known to show signifioant anti-implantational or anti-deoidual activities, we have synthesized two new steroidal ketones la and 1b possessing both the 7α-or 7β-methyl group and the 10β-aoetozy substitutions aooording to the following reaotion sequenoe.