化学学报 ›› 1983, Vol. 41 ›› Issue (10): 871-876. 上一篇    下一篇

研究论文

1-乙酰胺基丙叉-1,1-二膦酸和1-丙酰胺基乙叉-1,1-二膦酸与碱土金属离子的螯合作用

罗勤慧;沈孟长;蒋凝;颜庆瑜;张明明;谢毓元   

  1. 南京大学配位化学研究所;中国科学院上海药物研究所
  • 发布日期:1983-10-15

The chelation of 1-acetamido-propylidene-1, 1-diphosphonic acid and 1-propionamido-ethylidene-1, 1-diphosphonic acid with alkaline earth metalions

LUO QINHUI;SHEN MENGCHANG;JIANG NING;YAN QINGYU;ZHANG MINGMING;XIE YUYUAN   

  • Published:1983-10-15

关键词: 膦酸 P, 膦酸 P, 络合物, 数, 乙叉, 丙酰胺 P, 异丙叉, 碱土金属络合物, 螯合效应, 乙酰氨基

1-Acetamido-propylidene-1, 1-diphosphonic acid (S-186) and 1-propionamido-ethylidene-1, 1-diphosphonic acid (S-106) were synthesized and their chelation with alkaline earth metal ions was studied by pH method at 30+/-0.1 C. The complexes MHL, ML, ML2 and M2L were formed in aqueous solutions, when the molar proportion of metal to ligand varied from 10:1 to 1:2. Their stability constants were determined and it was found that the complexes of S-186 were more stable than those of S-106 and that there was a close relationship between the stability of the complexes and basicity of the ligands. It was also noticed that their binuclear complexes with Sr(II) were more stable than those with other alkaline earth metal ions.

Key words: PHOSPHONIC ACID P, PHOSPHONIC ACID P, COMPLEX COMPOUNDS, NUMBERS, ETHYLIDENE, PROPANAMIDE P, ISOPROPYLIDENE, ALKALINE EARTH METAL COMPLEX, CHELATE EFFECT, ACETAMIDO GROUP

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