化学学报 ›› 1983, Vol. 41 ›› Issue (6): 566-569. 上一篇    下一篇

研究论文

氧化铝柱上的Beckmann重排反应--一个新的异︽唑啉环合付产物

仇缀百;朱淬砺   

  1. 上海第一医学院药学系
  • 发布日期:1983-06-15

Beckmann rearrangement on alumina column -- a novel isoxazoline by-product

CHOU ZHUIBAI;ZHU CUILI   

  • Published:1983-06-15

关键词: 对甲苯磺酸, 氧化铝, 蒂巴因, 贝克曼重排, 异恶唑 P

By using Beckmann rearrangement on alumina to prepare 7α-acetylamino-6, 14-endo-etheno-tetrabydrothebaine (2a) and its N-allyl analogue (2b) from the corrssponding ketoxime tosylates (1a and 1b), we obtained novel isoxazoline by-products (3a and 3b). Their structures were determined by IR, ^1H NMR, MS and elemental analyses. The mechanism of this side reaction was beiefly discussed.

Key words: P-METHYLBENZENESULFONIC, ALUMINIUM OXIDE, THEBAINE, BECKMANN REARRANGEMENT, ISOXAZOLE P

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