化学学报 ›› 1988, Vol. 46 ›› Issue (10): 1053-1054. 上一篇    

研究论文

美丽红豆杉二萜的研究 II: 一个新的紫杉烷二萜的结构

梁敬钰;闵知大;丹羽正武   

  1. 中国药科大学植化教研室;日本名城大学
  • 发布日期:1988-10-15

Studies on the diterpenes of taxus mairei II: Structure of 2-deacetoxy-taxinine

LIANG JINGYU;MIN ZHIDA;DAN YUZHENGWU   

  • Published:1988-10-15

报导了从美丽红豆杉茎皮中分到的两个紫杉烷二萜化合物: 经高分辨核磁共振和COSY测定其结构为红豆杉素J(taxinine J)和2-去乙酰氧基-红豆杉素J(2-deacetoxytaxinine J), 后者系一新化合物, 药理结果表明: 二个化合物对肝癌细胞具有不同程度抑制作用.

关键词: 抗癌药, 萜类化合物, 质子磁共振谱法, 红豆杉科, 红豆杉素

A new taxane diterpene (I) and the known taxinin J (II) have been isolated from the bark of T. mairei collected in Fujian Province. The structure of I was determine to be 2-deacetoxytaxinin J on the basis of spectral anal. Both I and II were shown to possess inhibitory activity on hepatoma cell in vitro.

Key words: ANTICARCINOGEN, TERPENE, PROTON MAGNETIC RESONANCE SPECTROMETRY, TAXACEAE, TAXININE

中图分类号: