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化学学报
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化学学报 ›› 1989, Vol. 47 ›› Issue (5): 428-433. 上一篇    下一篇

研究论文

具有生物活性的金属配合物的研究 IV: 3,6-二(二甲氨基)-二苯并碘六环稀土二(氨三乙酸)配合物的合成、性质及抗肿瘤活性

陈淑英;刘展良;侯自杰;李笃;王欣;傅萍;张培   

  1. 兰州大学化学系;兰州医学院药学系
  • 发布日期:1989-05-15

Study on biologically active coordination compounds of metal ions IV: Synthesis, characterization and antitumor activity of rare earth bis(nitrilotriacetate) complexes of 3,6-di(dimethylamino)-dibenzopyriodonium

CHEN SHUYING;LIU ZHANLIANG;HOU ZIJIE;LI DU;WANG XIN;FU PING;ZHANG PEI   

  • Published:1989-05-15

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合成了十五种3,6-(二甲氨基)-二苯并碘六环稀土二(氨三乙酸)配合物,[C17H20N2I]3{RE[N(CH2CO2)3]2}.nH2O(RE=La, Eu, Er. n=3; RE=Ce-Nd, b-Ho, Tm,Yb. Y. n=4; RE=Sm, Gd, Lu. n=5). 利用X射线粉末衍射, 热重-差热分析、红外光谱、紫外光谱、^1H-NMR及摩尔电导等对这些配合物进行了表征. 实验表明, 镧配合物对体外L1210癌细胞生长有较好的抑制效果, 对小鼠S180肿瘤生长的抑制效果高于其前体.

关键词: 紫外分光光度法, 抗癌药, 红外分光光度法, Ｘ射线衍射分析, 钇络合物, 氨三乙酸 P, 钬络合物, 稀土金属络合物, 铈络合物, 热重量分析

[C17H20N2I]3{RE[N(CH2CO2)3]2}.nH2O (C17H20N2I = 3,6-di(dimethylamino) dibenzopyriodonium; RE = La, Eu, Er, n = 3; RE = Ce-Nd, Tb-Ho, Tm, Yb, Y, n = 4; RE = Sm, Gd, Lu, n = 5) were prepared The complex salts were characterized by x-ray powder diffraction TG-DTA, IR, UV, 1H NMR and molar conductances. The antitumor activity of the La complex was studied on transplanted mouse tumor S180 in vivo and mouse lymphocytic leukemia cell (L1910) in vitro. The results showed that the La complex is more effective than its precursors. The Dy complex is monoclinic, space group P212121, a 1.5154(2), b 1.8234(3), c 2.4010 ? Z = 4, dc = 1.751 g cm-3.

Key words: ULTRAVIOLET SPECTROPHOTOMETRY, ANTICARCINOGEN, INFRARED SPECTROPHOTOMETRY, X-RAY DIFFRACTION ANALYSIS, YTTRIUM COMPLEX, NITRILOTRISACETIC ACID P, HOLMIUM COMPLEX, RARE EARTH METAL COMPLEX, CERIUM COMPLEX, THERMOGRAVIMETRY

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