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化学学报
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化学学报 ›› 1994, Vol. 52 ›› Issue (3): 268-273. 上一篇    下一篇

研究论文

含酚醚中心功能基的大二环型穴醚的合成及配位性能

秦圣英;杨玉社;张安将   

  1. 四川大学化学系;华西医科大学药学院
  • 发布日期:1994-03-15

Synthesis of macrobicyclic cryptands with a phenol ether central group and their complexation

QIN SHENGYING;YANG YUSHE;ZHANG ANJIANG   

  • Published:1994-03-15

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365

被引次数

3 | 1

4-氯-2, 6-二羟基苯甲醚(2)与氯乙酸钠缩合, 制得4-氯-2, 6-二(羟甲氧基甲基)苯甲醚(4), 由4经酰氯化生成4-氯-2, 6-二(3-氯甲酰基-2-氧杂丙基)苯甲醚(5)后, 再与相应的二氮杂冠醚3a, 3b和3c反应制备标题化合物1a~1c。用1^H NMR法研究了1a~1c对碱金属离子的配位性能, 讨论了分子内的中心功能基和底环大小对其IR, 1^H NMR和配位行为的影响。

关键词: 红外分光光度法, 质子磁共振谱法, 穴醚, 苯甲醚 P, 冠醚, 配位性能, 氯乙酸钠

Three novel macrobicyclic cryptands I (n = 1-3) were synthesized by the reaction of diaza-15-crown-5, diaza-18-crown-6, and diaza-21-crown-7 with 4-chloro-2,6-bis(3-chlorocarbonyl-2-oxapropyl)anisole prepared from 4-chloro-2,6-bis(3-carboxyl-2-oxapropyl)anisole, which was obtained via the condensation of 4-chloro-2,6-dihydroxymethylanisole with Na chloroacetate. The complexation of I for alkali metal cations were studied by 1H NMR. The influence of central group and bottom ring size in the mols. I on IR, 1H NMR and complexation behavior is also discussed.

Key words: INFRARED SPECTROPHOTOMETRY, PROTON MAGNETIC RESONANCE SPECTROMETRY, CRYPTAND, ANISOLE P, CROWN ETHER

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