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化学学报
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化学学报 ›› 1996, Vol. 54 ›› Issue (10): 1030-1036. 上一篇    下一篇

研究论文

碱退式辅酶B~1~2类似物的合成和光谱性质

罗来斌;燕红;陈慧兰;唐雯霞   

  1. 南京大学化学系;南京大学配位化学国家重点实验室
  • 发布日期:1996-10-15

Synthesis and spectroscopic properties of coenzyme B~1~2 base-off form analogues

LUO LAIBIN;YAN HONG;CHEN HUILAN;TANG WENXIA   

  • Published:1996-10-15

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本工作用改进的方法合成了一类新的辅酶B~1~2碱退式类似物-含2'-脱氧核苷钴啉醇酰胺。它们分别是2',5'-二脱氧尿苷钴啉醇酰胺(2'dUrdCbi), 2',5'-二脱氧腺苷钴啉醇酰胺(2'dAdoCbi), 2',5'-二脱氧胞苷钴啉醇酰胺(2'dCytCbi)以及5'-脱氧胸苷钴啉醇酰胺(ThyCbi)。研究了它们的UV-Vis和^1H NMR光谱性质。并且和相应钴胺素的有关性质作了比较。

关键词: 类似物, 光谱性质, 脱氧核苷, 其它基金, 辅酶B~1~2, 钴啉醇酰胺

A new kind of analogues of coenzyme B~1~2 base-off form, which are cobinamides containing 2'-deoxynucleosides, were synthesized by an improved method. They are 2',5'-dideoxyuridinylcobinamide, 2',5'- dideoxyadenosylcobinamide, 2',5'-dideoxycytidylcobinamide, and 5'- deoxythymidylcobinamide. All the four analogues were investigated by UV-Vis and 2D ^1H NMR spectroscopies. The spectroscopic properties with those of their corresponding cobalamins were compared.

Key words: ANALOGUE, SPECTRAL PROPERTIES, DEOXYRIBONUCLEOSIDE, COBINAMIDE

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